2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR)

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HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes. The phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea.

Both in eukaryotes and in archaebacteria the enzyme HMGCR is known to catalyze an early reaction unique to isoprenoid biosynthesis. In humans, the HMG-CoA reductase reaction is rate-limiting for the biosynthesis of cholesterol and therefore constitutes a prime target of drugs that reduce serum cholesterol levels.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2924
    β-Amyrin palmitate
    		Inhibitor
    β-Amyrin palmitate shows HMG-CoA reductase inhibition. And β-Amyrin palmitate has anti-diabetes mellitus activity.
    β-Amyrin palmitate
  • HY-N10076
    Ganomycin I
    		Inhibitor
    Ganomycin I is a dual inhibitor of α-Glucosidase and HMG-CoA reductase. Ganomycin I can also inhibits HIV protease. Ganomycin I exhibits anti-diabetic and anti-osteoclastogenesis effects.
    Ganomycin I
  • HY-101873S
    Atorvastatin lactone-d5
    		Inhibitor
    Atorvastatin lactone-d5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].
    Atorvastatin lactone-d<sub>5</sub>
  • HY-RS06239
    Hmgcr Mouse Pre-designed siRNA Set A
    		Inhibitor

    Hmgcr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hmgcr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Hmgcr Mouse Pre-designed siRNA Set A
    Hmgcr Mouse Pre-designed siRNA Set A
  • HY-17502S
    Simvastatin-d11
    Simvastatin-d11 is the deuterium labeled Simvastatin. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].
    Simvastatin-d<sub>11</sub>
  • HY-RS06238
    HMGCR Human Pre-designed siRNA Set A
    		Inhibitor

    HMGCR Human Pre-designed siRNA Set A contains three designed siRNAs for HMGCR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    HMGCR Human Pre-designed siRNA Set A
    HMGCR Human Pre-designed siRNA Set A
  • HY-N0504S1
    Lovastatin-d9
    		Inhibitor
    Lovastatin-d9 is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
    Lovastatin-d<sub>9</sub>
  • HY-147195
    QH536
    		Inhibitor
    QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research.
    QH536
  • HY-B0165AS
    Pravastatin-13C,d3 sodium
    		Inhibitor
    Pravastatin-13C,d3 (sodium) is the 13C- and deuterium labeled Pravastatin (sodium). Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
    Pravastatin-<sup>13</sup>C,d<sub>3</sub> sodium
  • HY-17504D
    (3S,5R)-Rosuvastatin
    		Inhibitor
    (3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
    (3S,5R)-Rosuvastatin
  • HY-119695
    Simvastatin acid
    		Inhibitor
    Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene.
    Simvastatin acid
  • HY-N0504S2
    Lovastatin-d3
    		Inhibitor
    Lovastatin-d3 is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.
    Lovastatin-d<sub>3</sub>
  • HY-155668
    HMG-CoA Reductase-IN-1
    		Inhibitor
    HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and OATP1B1 affinity with pIC50 and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia.
    HMG-CoA Reductase-IN-1
  • HY-101873R
    Atorvastatin lactone (Standard)
    		Inhibitor
    Atorvastatin lactone (Standard) is the analytical standard of Atorvastatin lactone. This product is intended for research and analytical applications. Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
    Atorvastatin lactone (Standard)
  • HY-16152
    Crilvastatin
    		Inhibitor
    Crilvastatin (PMD 387) is a potent inhibitor of HMG-CoA reductase.
    Crilvastatin
  • HY-109523S
    Cerivastatin-d3 sodium
    		Inhibitor
    Cerivastatin-d3 sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.
    Cerivastatin-d<sub>3</sub> sodium
  • HY-135358
    (Rac)-5-Keto Fluvastatin
    		Inhibitor
    (Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) is an impurity of Fluvastatin (XU 62320). Fluvastatin is a HMG-CoA reductase inhibitor with an IC50 of 8 nM.
    (Rac)-5-Keto Fluvastatin
  • HY-135402
    2'-Ethyl Simvastatin
    		Inhibitor
    2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition.
    2'-Ethyl Simvastatin
  • HY-RS06240
    Hmgcr Rat Pre-designed siRNA Set A
    		Inhibitor

    Hmgcr Rat Pre-designed siRNA Set A contains three designed siRNAs for Hmgcr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Hmgcr Rat Pre-designed siRNA Set A
    Hmgcr Rat Pre-designed siRNA Set A
  • HY-117581
    L-669,262
    		Inhibitor
    L-669,262, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC50 of 0.10 ng/mL for rat liver HMG-CoA.
    L-669,262
Cat. No. Product Name / Synonyms Application Reactivity